Understanding Enediyne−Protein Interactions: Diyl Atom Transfer Results in Generation of Aminoacyl Radicals
- 1 March 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (6) , 811-813
- https://doi.org/10.1021/ol0055566
Abstract
The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodatively stabilized radicals.Keywords
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