Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport
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- 9 June 2000
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 288 (5472) , 1796-1802
- https://doi.org/10.1126/science.288.5472.1796
Abstract
Experiments with vesicles containingN-methyl-d-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.Keywords
This publication has 31 references indexed in Scilit:
- Actin-Dependent Propulsion of Endosomes and Lysosomes by Recruitment of N-Wasp✪The Journal of cell biology, 2000
- Generation and Maintenance of Neuronal Polarity: Mechanisms of Transport and TargetingNeuron, 1999
- Dissecting Dendrite DynamicsScience, 1999
- KIFC2 Is a Novel Neuron-Specific C-Terminal Type Kinesin Superfamily Motor for Dendritic Transport of Multivesicular Body-Like OrganellesNeuron, 1997
- Ion channel associated proteinsCurrent Opinion in Neurobiology, 1996
- Synaptic targeting of glutamate receptorsCurrent Opinion in Cell Biology, 1996
- Relationship between N-Methyl-D-aspartate Receptor NR1 Splice Variants and NR2 SubunitsJournal of Biological Chemistry, 1996
- Exclusive Expression of Kinesin Gene in Chemosnsory Neurons Open to the External EnvironmentJournal of Molecular Biology, 1995
- Changing subunit composition of heteromeric NMDA receptors during development of rat cortexNature, 1994
- C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like proteinNeuroReport, 1993