Effect of Factors other than Choline on Liver Fat Deposition.

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Abstract
Factors other than choline affect fat deposition in the liver of rats. When low protein diets were employed containing an adequate level of choline, fatty livers persisted which could not be alleviated by methionine although the growth rate was increased by this addition. The availability of niacin to the animal affected this fat deposition. Dextrin, when used as the carbohydrate source, was more effective in lowering liver lipids and increasing growth than sucrose. Casein, when added to the low-protein diet increased growth and decreased liver fat deposition proportionately to the amt. added to the diet. Gelatin decreased liver fat deposition but had a depressing effect on growth. Single amino acids such as proline and alanine may be involved in this liver fat reduction. Certain mixtures of amino acids are indicated as being more effective in liver lipid reduction than amino acids added singly. The factors involved in growth and liver fat deposition do not appear to be identical.