Immundiagnostische Befunde beim „sekundären” Sjögren-Syndrom bei chronischer Polyarthritis

Publisher Website
Google Scholar
Abstract
In order to characterize typical findings in patients (pts.) with secondary Sjogren''s Syndrome (SS) associated with rheumatoid arthritis (RA), 173 patients with RA were studied. Pathological screening-test resuls (Schirmer- and Saxon-test) were followed by ENT- and ophthalmological investigations and examinations in the field of internal medicine. Secondary SS associated with RA was diagnosed in 34 pts. (20%). Immuno-serological SS-A and/or SS-B-antibodies were found in 11 (32%) of 34 patients. 9 pts. (27%) had antinuclear antibodies. Abnormal titers of circulating immune complexes were present in the sera of 24 pts. (71%), salivary gland-antibodies in 3 pts. (9%). In 16 of 34 pts. (47%) minor salivary gland biopsy was performed. Lymphoplasmacellular sialadenitis could be verified in all pts. Immuno-histological reactions to anti-IgG and/or anti-IgM and/or antiIgA were detected in 10 (62%) of 16 pts. We could not find a single criterion to ascertain the diagnosis SS which still has to be made by considering all clinical and serological findings. Immunological findings may provide helpful and interesting diagnostic aspects which by long term observation may even gain importance; however, no differential therapeutic consequences can be seen at the moment.

This publication has 0 references indexed in Scilit: