Glutethimide Poisoning

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Abstract
THE coma induced by large overdoses of glutethimide (Doriden) is similar to that produced by the barbiturates. The clinical course of the glutethimide-intoxicated patient, however, is often complex. The coma may be of unusually long duration, with unexplained variations in depth.1 2 3 Management of glutethimide intoxication is further complicated by a poor correlation between the concentration of glutethimide in plasma and the clinical course of the patient.4 5 6 7 Although other explanations can be offered, the peculiarities associated with glutethimide intoxication could involve the formation and accumulation of an active metabolite. Ambre and Fischer8 have advanced this hypothesis by showing that 4-HG (4-hydroxy-2-ethyl-2-phenylglutarimide), . . .