EFFECT OF A SINGLE BOLUS OF ETOMIDATE UPON EIGHT MAJOR CORTICOSTEROID HORMONES AND PLASMA ACTH

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Abstract
In a prospective controlled trial we investigated the effect of an induction dose of etomidate (0.26 mg/kg i.v.) on plasma ACTH, progesterone, 17αOH‐progesterone, 11‐deoxycortisol, cortisol, cortisone, corticosterone, 11‐deoxycorticosterone, and aldosterone in seven males undergoing general anaesthesia. Seven other male patients receiving thiopentone at induction (5.0 mg/kg i.v.) served as controls. Plasma ACTH concentrations rose higher in the etomidate group (346 ± 124 vs. 117 ± 74 pg/ml, mean ± SEM), but the difference was not significant. After etomidate we found a clear suppression of plasma cortisol (PPPP<0.05) compared to corticosteroid levels after induction with thiopentone. Plasma 11‐deoxycortisol and 11‐deoxycorticosterone concentrations were grossly elevated 210 min after etomidate (91 ± 28 nmol/1 and 7.04 ± 0.47 nmol/1, respectively, P<0.01) demonstrating inhibition of 11β‐hydroxylation of both glucocorticoid and mineralocorticoid intermediates. In contrast, no significant difference in plasma progesterone and 17α‐OH‐progesterone levels was found between the two groups indicating that the cholesterol‐side‐chain cleavage enzyme is less sensitive to etomidate than 11β‐hydroxylase. Our results suggest that after induction of anaesthesia with a single bolus of etomidate, inhibition of other enzymes in the corticosteroid‐synthetic pathway (e.g. cholesterol‐side‐ chain cleavage enzyme) is of little clinical relevance.