THE INTRAPERITONEAL USE OF SULFATHIAZOLE, WITH SPECIAL REFERENCE TO THE PRODUCTION OF ADHESIONS

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Abstract
The intraperitoneal use of sulfanilamide and sulfathiazole to combat infective processes is without question an established procedure. These drugs are most frequently applied in those infections secondary to acute appendicitis. Sulfanilamide, the most frequently used, is said not to produce peritoneal adhesions. There is considerable evidence to support this view.1Several authors express the same conviction concerning sulfathiazole.2However, there is evidence3that it produces peritoneal irritation in the dog, while sodium sulfathiazole produces dense peritoneal adhesions in the same animal.3 A difference of opinion exists on the question of inhibition of wound healing after local implantation of these drugs,4but there seems little question that in certain instances this does occur.5 My purpose in this communication is to report a case of acute perforative gangrenous appendicitis with peritonitis in which the intraperitoneal use of sulfathiazole was followed by adhesions, intestinal obstruction and secondary

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