The effect of mebendazole and praziquantel on the cysts ofEchinococcus granulosus, Taenia hydatigenaandT. ovisin sheep

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Abstract
DWhen administered orally at 50 mg/kg live weight to sheep for 14 days mebendazole killed almost all Taenia hydatigena dand T. ovis dcysts and significantly retarded the growth of Echinococcus granulosus cysts. A single subcutaneous injection of mebendazole at 50 mg/kg was ineffective and was only partially effective when injected at this rate into the peritoneal cavity. The lack of effect was attributed to the slow solubilization of the injected depot. Praziquantel injected subcutaneously at 50 mg/kg disappeared from the injection site within three weeks. All T. hydatigena dcysts were killed in sheep harbouring up to 100 cysts, but not in those with more than this number. All T. ovis dcysts were apparently killed. This drug had no effect on E. granulosus. dThe lethal effect of intraperitoneally injected mebendazole, and of praziquantel, on T. hydatigena cysts was related to the biomass of cysts.