Examination of Rat Placental Lactogen and Prolactin at 6-hr Intervals during Midpregnancy

Abstract
The Nb2 node [rat] lymphoma cell bioassay was verified in the laboratory as a sensitive, reproducible and accurate bioassay for measurement of serum rat placental lactogen (rPL). Blood samples taken every 6 h during pregnancy showed a significant peak of rPL secretion in the late afternoon on day 11. The inverse relationship between rPL and nocturnal prolactin (PRL) surges is shown.

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