Antibody Response to Related Leukosis Viruses Induced in Chickens Tolerant to an Avian Leukosis Virus2
- 1 February 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (2) , 381-386
- https://doi.org/10.1093/jnci/56.2.381
Abstract
White Leghorn chickens congenitally infected with a subgroup A avian leukosis virus AlV-F42 were challenged at various ages with the serologically related subgroup A avian leukosis viruses (AlV) RAV-l, RAV-3, and RAV-5 and their anti- body responses and viremic status determined. Birds given injections of RAV-l failed to produce neutralizing antibody to any of the pseudotype sarcoma viruses of the various AlV, whereas many birds challenged with RAV-3 or RAV-5 produced neutralizing antibody directed against the heterologous RAV-l as well as the homologous viruses, but not against the tolerated virus AlV-F42. Virtually all birds remained viremic despite the presence of neutralizing antibody. The results suggested that a phenomenon akin to circumvention or abrogation of tolerance to AlV-F42 was effected, and that there are multiple determinants of the viral envelope antigens of AlV as measured by neutralization.Keywords
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