NITRIC OXIDE SYNTHASE: Role as a Transmitter/Mediator in the Brain and Endocrine System
- 1 February 1996
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 47 (1) , 219-227
- https://doi.org/10.1146/annurev.med.47.1.219
Abstract
▪ Abstract Nitric oxide is a unique biological messenger molecule. It is produced by endothelial cells to mediate blood vessel relaxation; it mediates, in part, the immune functions of activated macrophages; and in the central and peripheral nervous system it serves as a neurotransmitter. In the nervous system, nitric oxide may regulate neurotransmitter release, it may play a key role in synaptic plasticity and morphogenesis, and it may regulate sexual and aggressive behavior. Under conditions of excessive formation, nitric oxide is emerging as an important neurotoxin.Keywords
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