Plasma complement and histamine changes in atopic dermatitis*

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Abstract
Patients (15) with atopic dermatitis were investigated to evaluate the total of complement [C] and histamine. In 5 patients total serum C hemolytic activity (CH50) was significantly decreased, as was the hemolytic activity of C components C2 (C2H50) and C3 (C3H50). By counter immunoelectrophoresis, split products of C3 were detected. There was no evidence for alternative pathway activation or the presence of an activator of the alternative pathway. In 3 patients, plasma histamine concentrations were elevated. The intensity of the C and histamine changes observed seemed correlated to the severity of the disease.