Absorption, distribution, and excretion of suprofen in mice of both sexes.

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Abstract
The disposition and metabolism of DL-2-(4-(2-thienylcarbonyl)phenyl)propionic acid (suprofen, S) [a nonsteroidal antiinflammatory drug] were evaluated in male and female mice. The radiometric findings following oral administration of 2 mg/kg of 3H-S to male and female mice showed similar patterns of absorption, distribution and excretion of the radioactivity. S was rapidly absorbed in mice of both sexes; blood levels after a single oral dose of 2 mg/kg of 3H-S reached maxima within 7.5 min. Blood radioactivity was mostly accounted for by unchanged S. Elimination of 3H-S from the blood was rapid. Most of the radioactivity was excreted in the urine and a portion in the feces within 24 h after oral administration of 2 mg/kg of 3H-S or 10 mg/kg of 14C-S. The only tissues with concentrations similar to or higher than that in the plasma were those involved in metabolism and excretion (liver and kidney). Other tissue levels, except for the stomach, were all very low and there was no evidence of accumulation of drug-related material in any tissue. Male mouse urine contained S, 2-(4-(2-thienylhydroxymethyl)phenyl)propionic acid, 2-(4-carboxyphenyl)propionic acid and 2 unknown metabolites, accounting for about 73% of the urinary radioactivity.