Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix‐assisted laser desorption/ionization mass spectrometry using ionic liquid matrices
- 18 December 2003
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 18 (2) , 141-148
- https://doi.org/10.1002/rcm.1293
Abstract
A major problem hampering the use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for quantitative measurements is the inhomogeneous distribution of analytes and matrices in solid sample preparations. The use of ionic liquids as matrices for the qualitative and quantitative analysis of low molecular weight compounds like amino acids, sugars and vitamins was investigated. The ionic liquid matrices are composed of equimolar combinations of classical MALDI matrices (sinapinic acid, α-cyano-4-hydroxycinnamic acid or 2,5-dihydroxybenzoic acid) with organic bases. These matrix systems allow a homogenous sample preparation with a thin ionic liquid layer having negligible vapour pressure. This leads to a facilitated qualitative and quantitative measurement of the analytes compared with classical solid matrices. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
Funding Information
- Bundesministerium für Bildung und Forschung
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