A COMPARISON OF 3 MEANS OF PRESSURIZED AEROSOL INHALER USE

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Abstract
Bronchodilator response to 200 .mu.g of fenoterol hydrobromide, using 3 different methods of inhalation from a pressurized aerosol metered-dose inhaler, was studied in 13 asthmatic patients. On 4 separate days and in random order, patients received placebo aerosol or fenoterol aerosol delivered by the patients'' own technique, delivered under supervision by a trained member of the staff and delivered with a spacer device (Aerochamber) attached to the pressurized canister. There was no significant difference in the response to the 3 methods of active drug administration but there was a significant difference (P < 0.05) from the placebo control values. In this group of asthmatics the patients'' own method of inhalation, using the standard dose of 200 .mu.g of fenoterol from a pressurized aerosol metered-dose inhaler, appears to be as effective a means of bronchodilation as the other techniques.