OXOTREMORINE-INDUCED CHOLINERGIC SYNDROME - MODIFICATIONS BY LEVODOPA AND OR ORAL CYTIDINE DIPHOSPHOCHOLINE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 7  (1) , 5-8
Abstract
A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration, pretreatment orally with diphosphocholine CDP-choline does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation. Levodopa antagonizes the oxotremorine-induced cerebral symptoms (akinesia-tremor); however, has antagonism disappears when mice are chronically pretreated orally with CDP-choline, confirming the action of CDP-choline on dopaminergic pathways. The proven efficacy of CDP-choline in Parkinsonism could then be mediated by a hypersensitivity of some cerebral dopamine receptors, and not by a direct stimulating effect of the striatal dopaminergic receptors.

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