A new silent hemoglobin variant in a black family from French West Indies
- 16 August 1982
- journal article
- Published by Wiley in FEBS Letters
- Vol. 145 (1) , 128-130
- https://doi.org/10.1016/0014-5793(82)81220-9
Abstract
A new abnormal hemoglobin Hb Le Lamentin α20 (B1) His→Gln was discovered during a survey of cord blood from the French West Indies (Martinique). This variant displays an electrophoretic pattern similar to that of Hb A but can be isolated by isoelectric focusing (IEF) and Biorex 70 chromatography. Family studies showed the presence of this hemoglobin variant in the father and in two of his three children. Hematological data from the carriers were normal.Keywords
This publication has 11 references indexed in Scilit:
- An update on electrophoretic and chromatographic methods in the diagnosis of hemoglobinopathiesJournal of Chromatography B: Biomedical Sciences and Applications, 1982
- Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.Proceedings of the National Academy of Sciences, 1980
- A Silent Hemoglobin Variant: Hemoglobin Necker Enfants-Malades α 20 (Bl) His → TyrHemoglobin, 1980
- Functional studies of Hb Malmö β97 (FG4) His → GLNFEBS Letters, 1977
- Crystal structure of sickle-cell deoxyhemoglobin at 5 Å resolutionJournal of Molecular Biology, 1975
- A Simple Method for the Detection of Unstable HaemoglobinsBritish Journal of Haematology, 1972
- Hemoglobin Components in Patients with Diabetes MellitusNew England Journal of Medicine, 1971
- Direct determination of 2,3-diphosphoglycerateAnalytical Biochemistry, 1970
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Estimation of Small Percentages of Fœtal HæmoglobinNature, 1959