EFFECT OF HISTAMINE ON MONOCYTE COMPLEMENT PRODUCTION .2. MODULATION OF PROTEIN SECRETION, DEGRADATION AND SYNTHESIS
- 1 January 1980
- journal article
- research article
- Vol. 42 (3) , 515-522
Abstract
Using immunofluorescence and pulse-label studies with 3H-labeled amino acids, histamine [H] was shown to inhibit the secretion of newly synthesized C2 [complement component 2], C4, C3, [complement] factor B and .beta.1H globulin by [human] monocytes in culture. Apparently protein synthesis was decreased and newly synthesized intracellular protein degradation was increased in H-treated monocytes. The observations that all monocytes in cultures containing H stained for C2, C4, C3, factor B and .beta.1H, when secretion was impaired, shows that all monocytes synthesize these proteins. A negative feedback loop on C3 and C5 cleavage is demonstrated. The anaphylotoxins, C3a and C5a, formed as a result of C3 and C5 cleavage, release H from mast cells and basophils. H, by inhibiting the production of C4, C2, C3 and factor B by mononuclear phagocytes, inhibits further C3 and C5 cleavage by restricting the formation of .**GRAPHIC**. .**GRAPHIC**. and .**GRAPHIC**.This publication has 11 references indexed in Scilit:
- Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes.The Journal of Experimental Medicine, 1980
- EFFECTS OF HISTAMINE ON MONOCYTE COMPLEMENT PRODUCTION .1. INHIBITION OF C2 PRODUCTION MEDIATED BY ITS ACTION ON H-2 RECEPTORS1980
- Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysisBiochemical Journal, 1979
- Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).Proceedings of the National Academy of Sciences, 1977
- Modulation of the alternative complement pathways by beta 1 H globulin.The Journal of Experimental Medicine, 1976
- Third component of human complement: purification from plasma and physicochemical characterizationBiochemistry, 1976
- Synthesis of the second component of complement by long-term primary cultures of human monocytes.The Journal of Experimental Medicine, 1976
- Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTIONJournal of Clinical Investigation, 1974
- Alternate Complement Pathway: Factors Involved in Cobra Venom Factor (CoVF) Activation of the Third Component of Complement (C3)The Journal of Immunology, 1973