Glomerular Lesions in ‘Normal’ and Schistosoma monsoni-Infected Baboons

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Abstract
Histopathological and immunohistochemical studies of the kidneys of 18 ‘normal’ captive baboons (Papio cynocephalus) revealed that, with increasing age, spontaneously occurring glomerular lesions tended to increase. They ranged from focal thickenings of the basement membrane or the mesangium matrix to more advanced lesions. In older animals, focal chronic glomerulitis was observed. Focal immunofluorescence was seen only in the minor histopathological lesions. The kidneys of nine baboons infected with Schistosoma monsoni did not differ from those of the ‘normal’ baboons. No significant immunoglobulin deposits could be demonstrated in the renal tissues from the infected animals.

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