Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence
Open Access
- 6 October 2000
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 14 (15) , 2495-2502
- https://doi.org/10.1096/fj.00-0209com
Abstract
Oxidized and cross-linked proteins tend to accumulate in aging cells. Declining activity of proteolytic enzymes, particularly the proteasome, has been proposed as a possible explanation for this phen...Keywords
Funding Information
- National Institutes of Health (ES03598)
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