Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes

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Abstract
A [rabbit liver] membrane receptor protein for asialoglycoproteins induces voltage-dependent increases in ion conductance across a lipid bilayer, probably reflecting penetration of the protein into the bilayer towards an electrically positive pole. In the presence of specific ligand for the receptor, this penetration leads to a translocation of the receptor from 1 side of the bilayer to the other. A mechanism was suggested by which biological membranes might regulate the disposition of their proteins and a way in which membrane receptors involved in endocytosis might be spared lysosomal destruction in order to be recycled to the plasma membrane.