Isolated Degenerative Amnesia Without Dementia: An 8-year Longitudinal Study

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Abstract
A case of a 72-year-old patient suffering from progressive isolated memory disorders is reported. The patient has been followed up over eight years and her neuropsychological profile reveals a high standard of performance on all tests assessing Intelligence, language, praxis, attention, and short-term memory, but she fails all long-term memory tasks. MRI images showed bilateral hippocampal atrophy in the sagittal and coronal sections in the absence of white matter signal abnormalities. [18FDG] PET scan detected bilateral hypometabolism of the hippocampal regions and of the thalamus and mild metabolic reduction in the frontal area. The neuroimaging and neuropsychologlcal profiles point to a progressive amnesia of degenerative aetiology.

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