Regulatory effect of endogenous calcitonin on calcium metabolism in hepatic bile system of rats.
- 1 January 1980
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 27 (3) , 381-385
- https://doi.org/10.1507/endocrj1954.27.381
Abstract
The effect of calcium chloride (4.0 mg Ca2+/100 g BW [body wt]) on the Ca metabolism in the hepatic bile system was investigated in intact and thyroparathyroidectomized rats. Ca administration did not alter the serum Ca of intact rats but increased it markedly in thyroparathyroidectomized rats. The administration of Ca to intact rats also caused a significant decrease in the liver plasma membrane Ca-ATPase activity, and a corresponding increase in liver Ca and bile Ca, while no such increase was seen in thyroparathyroidectomized rats. Calcitonin administration (CT, 80 Medical Research Council mU/100 g BW) to intact rats significantly lowered both serum Ca and liver plasma membrane. Ca-ATPase activity and significantly elevated both liver and bile Ca. Apparently endogenous CT regulates Ca metabolism in the hepatic bile system of rats after calcium chloride injection.This publication has 1 reference indexed in Scilit:
- Maximum Biliary Excretion of Bilirubin and Sulfobromophthalein During Anesthesia-Induced Alteration of Rectal Temperature.Experimental Biology and Medicine, 1967