Differential Expression of Apolipoprotein-D and Prostate Specific Antigen in Benign and Malignant Prostate Tissues
- 1 August 1995
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 154 (2) , 622-628
- https://doi.org/10.1016/s0022-5347(01)67123-4
Abstract
To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues. Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D sub 2 prostate cancers. Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p less than 0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates. Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.Keywords
This publication has 15 references indexed in Scilit:
- Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cellsEndocrinology, 1992
- Secretion of breast gross cystic disease fluid proteins by T47D breast cancer cells in culture — modulation by steroid hormonesBreast Cancer Research and Treatment, 1992
- Tissue concentrations of prostate-specific antigen in prostatic carcinoma and benign prostatic hyperplasiaInternational Journal of Cancer, 1991
- Apolipoprotein D transcription occurs specifically in nonproliferating quiescent and senescent fibroblast culturesFEBS Letters, 1991
- Immunologic and steroid binding properties of the GCDFP-24 protein isolated from human breast gross cystic disease fluidBreast Cancer Research and Treatment, 1990
- The Immunopathology of Gross Cystic Disease Fluid ProteinsAnnals of the New York Academy of Sciences, 1990
- Immunohistochemical distribution of the three predominant secretory proteins in the parenchyma of hyperplastic and neoplastic prostate glandsThe Prostate, 1988
- Changes in immunohistochemical staining in prostatic adenocarcinoma following diethylstilbestrol therapyThe Prostate, 1985
- Characterization and immunoassay of apolipoprotein DAtherosclerosis, 1981
- Studies on the isolation and partial characterization of apolipoprotein D and lipoprotein D of human plasmaBiochemistry, 1976