A common mutant EcoRI restriction endonuclease site in the 5' flanking portion of the human alpha-globin gene.
- 1 November 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (11) , 7056-7058
- https://doi.org/10.1073/pnas.78.11.7056
Abstract
A mutant EcoRI endonuclease restriction site was identified in 3 of 37 black subjects and in 2 sibs of 1 of these persons. This mutation was not encountered in 13 whites. It is located approximately 6 kilobases inside the normal site in the 5'' flanking sequence of the .alpha.-globin chain complex. The shortened .alpha.-globin gene-bearing segment produced in the EcoRI digest produces a restriction map similar to that observed for the common .alpha.-globin gene deletion observed in the black population. The restriction map with BamHI is normal, confirming that all 4 .alpha. loci are present.This publication has 10 references indexed in Scilit:
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