EFFECTS OF BORDETELLA-PERTUSSIS VACCINE ON CEREBRAL VASCULAR-PERMEABILITY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (6) , 653-662
Abstract
The effect of B. pertussis vaccine on cerebral vascular permeability in the mouse was studied with 131I-labeled human serum albumin. I.v. injection of 4 .times. 1010 heat-killed pertussis organisms caused a measurable increase in permeability in normal mice. Cryoinjury to the cerebral hemispheres resulted in a striking increase in vascular permeability at 24 h. This declined within 48 h and stabilized at a level fractionally higher than normal at 7 days (healed lesion). When pertussis organisms were injected into mice bearing healed lesions the increase in permeability was similar in magnitude to that in uninjured brain. The effect was increased by a 2nd administration of pertussis 24 h after the 1st. The action of pertussis on a newly inflicted cryoinjury was protective. Permeability changes in the cerebral vessels may be involved in the evolution of the encephalopathy attributed to the use of B. pertussis vaccine in man.