STANNOUS TRIFLATE MEDIATED ALDOL REACTION OF 3-ACYLTHIAZOLIDINE-2-THIONE: A CONVENIENT METHOD FOR THE STEREOSELECTIVE SYNTHESES OF β-HYDROXY ALDEHYDE AND β-HYDROXY CARBOXYLIC ACID DERIVATIVES
- 5 December 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 11 (12) , 1903-1906
- https://doi.org/10.1246/cl.1982.1903
Abstract
Divalent tin enolates, formed from stannous triflate and 3-acylthiazolidine-2-thiones, react with aldehydes to afford the corresponding aldol products in high yields with high erythroselectivities. The adducts are easily transformed into β-hydroxy aldehyde and β-hydroxy carboxylic acid derivatives.Keywords
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