A Critical Evaluation of the Hypotensive Action of Hydrallazine, Hexamethonium, Tetraethylammonium and Dibenzyline Salts in Human and Experimental Hypertension

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Abstract
The effects of hydrallazine and hexamethonium salts on blood pressure and related functions have been studied in a series of ambulatory and hospitalized hypertensive patients as well as in experimentally induced hypertension (rats and dogs). Comparative observations have also been made on the effects of tetraethylammonium chloride and Dibenzyline, a congener of dibenzylchlorethylamine (Dibenamine). Critical evaluation of the data indicates that the effectiveness of hydrallazine and hexamethonium salts, when used either alone or in combination, is not significantly greater in long term administration than that of previously existing regimens in the treatment of hypertensive vascular disease.