Synthesis of quinones having carboxy- and hydroxy-alkyl side chains, and their effects on rat-liver lysosomal membrane.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (8) , 2797-2819
- https://doi.org/10.1248/cpb.30.2797
Abstract
To study the structure-activity relationship of metabolites of ubiquinone, .alpha.-tocopherol and phylloquinone, 3-carboxy-2-butenyl, 6-hydroxy-3-methyl-2-hexenyl, 4-hydroxy-3-methylbutyl, 4-hydroxy-3-methyl-2-butenyl, .omega.-carboxyalkyl and .omega.-hydroxyalkyl side chains were introduced into the 6-position of 2,3-dimethoxy-5-methyl-1,4-benzoquinone and 2,3,5-trimethyl-1,4-benzoquinone as well as the 3-position of 2-methyl-1,4-naphthoquinone. The effects of these quinones on the membrane stability of rat-liver lysosomes and on the activity of bovine heart phosphodiesterase were investigated. A good correlation was observed between these activities of the benzoquinone derivatives.This publication has 2 references indexed in Scilit:
- Über die Chemie des Vitamins E. 3. Mitteilung. Die Totalsynthese von (2R, 4′R, 8′R)‐ und (2S, 4′R, 8′R)‐α‐TocopherolHelvetica Chimica Acta, 1963
- ADENOSINE 3',5'-PHOSPHATE IN BIOLOGICAL MATERIALS .1. PURIFICATION AND PROPERTIES OF CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE AND USE SF THIS ENZYME TO CHARACTERIZE ADENOSINE 3',5'-PHOSPHATE IN HUMAN URINE1962