Influence of Desiccated Thyroid and Iodine on Growth-II. With a Standard Acid Diet

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Abstract
Rats were fed a diet of yellow corn, wheat bran, and oats (1-1-3) with and without glucose (17.5-22.5 gm. Karo syrup). Without glucose this was adequate in vitamins A, B and probably E for normal growth and reproduction. Pregnancy occurred in all mature 9 9 (6 mos.). Certain animals of each group were fed 1-2 grains of desiccated thyroid daily, which doses were not sufficient to cause resorption of the fetuses, but were injurious to the mother and to the young, which died a few days after birth probably as a result of disturbed lactation in the mother. In young rats (2 mos.) with glucose, thyroid feeding produced a steady gain in weight, while in the absence of thyroid this diet produced early maturity and led to early pregnancies (95 days). Low thyroid dosage induced growth of the bones with increased body-weight. With glucose thyroid feeding probably stimulates an increased output of energy. A possible relationship between vitamin B, inosite and glucose is suggested. Adult rabbits given similar diets with and without KI developed respiratory disturbances probably due to a vitamin deficiency. When young were produced they were devoured by the mother.

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