Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens
- 1 July 2004
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 319 (4) , 1322-1326
- https://doi.org/10.1016/j.bbrc.2004.05.116
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic ActivityThe Journal of Pharmacology and Experimental Therapeutics, 2003
- Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infectionClinical Pharmacology & Therapeutics, 2003
- Role of polymorphic human CYP2B6 in cyclophosphamide bioactivationThe Pharmacogenomics Journal, 2003
- Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics studyThe Lancet, 2002
- Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.Published by Rockefeller University Press ,2001
- Identification and functional characterization of eight CYP3A4 protein variants.Published by Rockefeller University Press ,2001
- Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patientsAIDS, 2001
- High-Performance Liquid Chromatography Method for Analyzing the Antiretroviral Agent Efavirenz in Human PlasmaTherapeutic Drug Monitoring, 1999
- EfavirenzDrugs, 1998