Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambiense sleeping sickness patients before and after treatment
- 1 May 2002
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 96 (3) , 329-333
- https://doi.org/10.1016/s0035-9203(02)90115-x
Abstract
Serum and cerebrospinal fluid (CSF) concentrations of interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α and interferon-γ were determined in 46 Trypanosoma brucei gambiense sleeping sickness patients in DR Congo, before and after treatment. According to their CSF cell number before treatment, patients were classified as early-stage (0–5 cells/μL), intermediate-stage (6–20 cells/μL) or late-stage patients (>20 cells/μL). In serum, slightly higher IL-8 concentrations were found in early-stage patients compared to intermediateor late-stage patients. These high IL-8 levels dropped after treatment. Higher IL-10 concentrations were detected in serum of patients in intermediate or late stage compared to early-stage patients. In both intermediate-and late-stage groups, serum IL-10 decreased after treatment. In CSF, elevated concentrations of IL-6, IL-8 and especially of IL-10 were observed in late-stage T. b. gambiense patients. After treatment, these concentrations dropped to levels similar to those of the other patients. Tumour necrosis factor-α was detected only in a few serum and CSF samples, which were scattered over the different patient groups. Interferon-γ was detected in serum of 5 patients and remained undetectable in CSF.Keywords
This publication has 14 references indexed in Scilit:
- Blood–cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sicknessJournal of the Neurological Sciences, 2002
- Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophagesParasite Immunology, 2000
- Attenuation ofTrypanosoma bruceiIs Associated with Reduced Immunosuppression and Concomitant Production of Th2 LymphokinesThe Journal of Infectious Diseases, 2000
- Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected withTrypanosoma bruceiJournal of Comparative Neurology, 1999
- Effect of Melarsoprol Treatment on Circulating IL-10 and TNF-α Levels in Human African TrypanosomiasisClinical Immunology and Immunopathology, 1997
- Interleukin-8 Released into the Cerebrospinal Fluid after Brain Injury is Associated with Blood–Brain Barrier Dysfunction and Nerve Growth Factor ProductionJournal of Cerebral Blood Flow & Metabolism, 1997
- Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis Factor-Alpha and Interleukin-6 Concentrations in African TrypanosomiasisNeuroimmunomodulation, 1994
- The somnogenic T lymphocyte suppressor prostaglandin D2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness patientsTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990
- Immunohistochemical characterization of the mononuclear cells in the brain of the rat with an experimental chronicTrypanosoma brucei gambiense infectionZeitschrift Fur Parasitenkunde-Parasitology Research, 1989
- Spread of Trypanosoma brucei to the nervous system: Early attack on circumventricular organs and sensory gangliaJournal of Neuroscience Research, 1988