Clinical and pathological observations with special reference to the nervous system in Macaca radiata infected with kyasanur forest disease virus

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Abstract
Monkeys inoculated with KFD virus developed diarrhoea, bradycardia and hypotension; those monkeys with bradycardla and hypotension died. The autonomic nervous system did not show a histological abnormality to account for the clinical findings. Lesions of the spinal cord are described for the first time in KFD. Phagocytosis of nuclear material and red blood cells was again seen in the peripheral blood. An increase in nuclear debris was seen also in the lymph glands of some in fected monkeys. These findings suggest an increase in nuclear destruction, probably of the white boood cells.