Effect of side-chain substitution of a CH2 group by sulfur on the antimicrobial activity of natural penicillins and cephalosporins.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (11) , 1550-1554
- https://doi.org/10.7164/antibiotics.38.1550
Abstract
The S-carboxymethyl-D-cysteine side-chain analogs of cephalosporin C and deacetoxycephalosporin C were found to have markedly increased in vitro activity against Gram-positive and Gram-negative bacteria compared to the natural antibiotics. The S-carboxymethyl-L-cysteine analogs were less active than the S-carboxymethyl-D-cysteine analogs but against most organisms tested, still more active than the natural compounds. The effect of replacement of CH2 with S was less dramatic in the case of penicillin N and isopenicillin N. The S-carboxymethyl-D-cysteine analog of deacetoxycephalosporin C was found to be orally available in rats.This publication has 5 references indexed in Scilit:
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