Kinetics of the Immune Response of Channel Catfish toEdwardsiella ictaluri

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Abstract
Kinetics of the immune response of channel catfish Ictalurus punctatus to Edwardsiella ictaluri were determined. The antibody titer of fish immunized with either cell extract or cell envelope increased gradually I week after intraperitoneal immunization and more rapidly thereafter until reaching a maximum titer 4 weeks after immunization. The antibody titers gradually declined after this point but were still detectable 11 weeks after immunization in vaccinated fish that did not receive a booster dose. An anamnestic response immediately followed a booster vaccination administered 6 weeks after initial vaccination, and the antibody titer increased in a short period of time. A whole-cell preparation of formalin-killed E. ictaluri injected intraperitoneally at a dose of 2.0 × 104 cells/fish produced lower antibody titers than did intraperitoneal injection of 2.0 × 106 or 2.0 × 108 cells/fish, but there was no difference in antibody titers from 2.0 × 106 and 2.0 × 108 cells/fish. A crude membrane prep...

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