Nerve growth factor: stimulation of polymorphonuclear leukocyte chemotaxis in vitro.

Publisher Website
Google Scholar
Abstract
Topical application of mouse nerve growth factor (NGF) to superficial skin wounds of mice has previously been shown to accelerate the rate of wound contraction. NGF in the presence of plasma apparently is also chemotactic for human polymorphonuclear leukocytes in vitro, and the concentration of NGF required for this effect is similar to that which stimulates ganglionic neurite outgrowth. This property does not arise from liberation of the C5a fragment of complement, nor does it require the known enzymic activity of NGF. (NGF inactivated with DFP is equally active.) NGF can display biological effects on cells of non-neural origin and function, and this feature might play a role in the early inflammatory response to injury.