Plasma vasopressin concentration in the anaesthetized dog before, during and after atrial distension.

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Abstract
Plasma vasopressin (AVP) concentration in dogs anesthetized with chloralose was measured by radioimmunoassay and was within the range of 2 to 5 pg/ml during control periods. Distension of the left atrium led within 2 min to a fall in plasma AVP concentration which reached a steady lower value within 4 min. After cessation of atrial distension the AVP concentration returned to pre-distension values within 4 min. Cooling the cervical vagosympathetic nerves to 8-10.degree. C led to a rise in plasma AVP concentration. Atrial distension during cooling of the vagi resulted in a further increase of plasma AVP concentration.

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