Chlorpromazine Effects on Macromolecular Syntheses in Synchronized Tetrahymena

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Abstract
Chlorpromazine (CPZ) inhibits synchronized cell division in Tetrahymena pyriformis with 100% inhibition occurring at 8 µg/ml. CPZ markedly inhibited the incorporation of precursors into DNA and RNA, but had little effect on the incorporation of acetate into lipids. Amino acid incorporation into protein was also blocked, however, uptake of amino acid by the cell was inhibited to a similar extent. This indicates that CPZ had no direct inhibitory effect on protein synthesis. The data presented here indicate that CPZ may have other sites of action with nucleic acid syntheses appearing to be potential sites of primary inhibition in T. pyriformis.

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