RELATIONSHIPS BETWEEN H‐2 AND VIRAL ANTIGENS IN MURINE ONCORNAVIRUS‐INDUCED TUMOURS*

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Abstract
SUMMARY: Cytolytic T lymphocytes (CTL) from murine sarcoma virus (MSV) or Friend leukaemia virus (FLV) inoculated mice lyse syngeneic much more efficiently than allogeneic FMRGi+ lymphoma cells. By comparing the cytolysis of various H‐2 different 51Cr lymphomas by CTL from several inbred and congenic lines differing at H‐2, and by competition experiments using unlabelled cells, one can demonstrate that this phenomenon is due to an H‐2 barrier. H‐2b/H‐2d hybrid‐anti‐MSV‐CTL immunized by H‐2b, H‐2d or H‐2b/H‐2d tumours lyse only FMRGi+ lymphomas of the same H‐2, and their activity for a given target is inhibited only by H‐2‐identical competitive cells. H‐2 antigens are therefore directly involved in the interaction between tumour cells and immune CTL which probably react with an 'H‐2 modified' antigen of the tumour cells surface. The use of CTL from intra‐H‐2 recombinant lines shows that H‐2D and probably H‐2K molecules are involved, but vary according to the tumour cells. A possible role of the I region is discussed as well as the implications of these results in immunosurveillance against viral neoplasia.

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