Plasma Interleukin?10:Tumor Necrosis Factor (TNF)–? Ratio Is Associated with TNF Promoter Variants and Predicts Malarial Complications
Open Access
- 1 November 2000
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 182 (5) , 1570-1573
- https://doi.org/10.1086/315857
Abstract
In individuals with severe malarial anemia, plasma levels of tumor necrosis factor (TNF)—α tend to exceed those of interleukin (IL)—10. In this study, IL-10:TNF plasma level ratios 1 (P = .008). In contrast, individuals with a mutation at position −238 of the TNF promoter (TNF−238A and TNF−376A/−238A) consistently had lower IL-10 than TNF plasma levels (IL-10:TNF ratio P = .003). Our results show that, in children with severe malaria, TNF promoter variants influence the balance of IL-10:TNF in the plasma, which, in turn, affects the outcome in terms of clinical complications.Keywords
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