Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina
- 1 March 1984
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 59 (1) , 1-7
- https://doi.org/10.1007/bf01249874
Abstract
The effects of (+)- and (−)-3-PPP on cAMP levels of rabbit retina were investigatedin vitro in the absence or presence of exogenous dopamine. In some experiments, a pre-incubation with reserpine was undertaken to deplete endogenous dopamine before the test. (+)- and (−)-3-PPP were found to be a weak dopamine-agonist and a weak dopamine-antagonist, respectively. Thus, the 3-PPP enantiomers may have opposite actions at the level of postsynaptic dopamine receptors, as previously suggested by studiesin vivo.This publication has 10 references indexed in Scilit:
- Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPPPsychopharmacology, 1983
- 3-PPP antagonizes the in vitro effects of D-1 and D-2 dopamine receptor agonists in rat neostriatumEuropean Journal of Pharmacology, 1983
- On the mode of action of 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP, and its enantiomers. With particular reference to dopaminergic mechanisms in the central nervous system.1983
- Inhibition of postsynaptic dopamine-sensitive adenylate cyclase in carp retina by the putative dopamine autoreceptor agonist, 3-PPPEuropean Journal of Pharmacology, 1982
- Interaction of the putative dopamine autoreceptor agonists, 3-PPP and TL-99, with the dopamine-sensitive adenylate cyclase of carp retinaEuropean Journal of Pharmacology, 1982
- 3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptorsLife Sciences, 1981
- Dopaminergic mechanisms in the carp retina: Effects of dopamine, K+ and light on cyclic AMP synthesisNeurochemistry International, 1980
- The isolated retina of mammals: A useful preparation for enzymatic-(adenylyl cyclase) and/or binding studies of dopamine receptorsNeurochemistry International, 1980
- Multiple receptors for dopamineNature, 1979
- A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphateBiochemical Journal, 1971