Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas
- 26 April 1974
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4135) , 482-484
- https://doi.org/10.1126/science.184.4135.482
Abstract
Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.Keywords
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