Recurrent involvement of the REL and BCL11Aloci in classical Hodgkin lymphoma
- 15 February 2002
- journal article
- Published by American Society of Hematology in Blood
- Vol. 99 (4) , 1474-1477
- https://doi.org/10.1182/blood.v99.4.1474
Abstract
Comparative genomic hybridization studies have shown gains in chromosome region 2p as the most common imbalance in classical Hodgkin lymphoma (cHL). The minimal region of gain contained 2 candidate oncogenes, REL and BCL11A . This study examined the involvement of REL and BCL11A loci in 44 primary cases of cHL by combined immunophenotyping and interphase cytogenetics (FICTION). A median 2p13 copy number above the tetraploid range was detected in 24 (55%) cases. Adjustment for centromere 2 copy number indicated gains of 2p13 in 11 of 31 cHLs (35%) with 8 (26%) high-level amplifications. One cHL displayed selective amplification of the REL locus not affecting BCL11A ; another case studied by FICTION and a cHL with cytogenetic 2p change investigated by fluorescence in situ hybridization showed signal patterns suggesting breakpoints in the region spanned by the REL probe. These data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL.Keywords
This publication has 24 references indexed in Scilit:
- Molecular‐cytogenetic comparison of mucosa‐associated marginal zone B‐cell lymphoma and large B‐cell lymphoma arising in the gastro‐intestinal tractGenes, Chromosomes and Cancer, 2001
- Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cellsBlood, 2001
- The use of real-time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphomaBritish Journal of Haematology, 2000
- The World Health Organization Classification of Hematological Malignancies Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997Laboratory Investigation, 2000
- Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's LymphomaThe Journal of Experimental Medicine, 2000
- Aberrant rel/nfkb genes and activity in human cancerOncogene, 1999
- Cytogenetics of Hodgkin’s diseaseCytogenetic and Genome Research, 1998
- The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activationCurrent Opinion in Immunology, 1998
- Defective IκBα in Hodgkin cell lines with constitutively active NF-κBOncogene, 1998
- Cytogenetics and molecular cytogenetics in Hodgkin's diseaseAnnals of Oncology, 1996