Proteinase inhibitors suppress the formation of granulation tissue in the carrageenin-induced inflammation in rats.

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Abstract
Effect of proteinase inhibitors on the carrageenan-induced inflammation was studied. The formation of granulation tissue was markedly inhibited by a single injection of .epsilon.-amino-n-caproic acid n-hexyl ester (EACA hexyl ester 300 mg/kg) into the carrageenan-air-pouch immediately after carrageenan injection, but repeated injections of the inhibitor starting at 12, 24 and 48 h after carrageenan injection were less effective, slightly effective and ineffective, respectively. A dose-dependent inhibition of both the formation of granulation tissue and the migration of polymorphonuclear leukocytes (PMN) into the inflammatory locus was found by a single injection of EACA hexyl ester into the carrageenan-air-pouch immediately after carrageenan injection. A single injection of L-1-tosylamide-2-phenylethylchloromethyl ketone (TPCK, 50 mg/kg) and N-.alpha.-p-tosyl-L-lysine chloromethyl ketone (TLCK, 30 mg/kg) inhibited both the formation of granulation tissue and the migration of PMN into the inflammatory locus. Serine proteinase inhibitors i.e., EACA hexyl ester, TPCK and TLCK exert their anti-inflammatory actions by interfering with the initial inflammatory reactions including the migration of PMN into inflammatory locus after carrageenan injection.

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