Biologically Active Metabolites from Fungi, 10. Generation of the Palmarumycin Spiroacetal Framework by Oxidative Cyclization of an Open Chain Metabolite from Coniothyrium palmarum
- 1 December 1997
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1997 (12) , 2531-2534
- https://doi.org/10.1002/jlac.199719971216
Abstract
The first “open chain” representative of the palmarumycins, the biaryl ether 1, was isolated from Coniothyrium palmarum. Phenol oxidation of 1 with silver oxide as a model for a biosynthetic step yielded 4 with the usual spiroacetal structure of the palmarumycins. The absolute (S)‐configuration of 4 (and thus of 1) was determined by quantumchemical CD calculations.Keywords
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