CYCLICAL COMBINATION CHEMOTHERAPEUTIC REGIMEN IN ADULT SOFT-TISSUE SARCOMA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 4  (2) , 163-165
Abstract
A cyclical combination chemotherapeutic regimen of adriamycin and cyclophosphamide alternating with actinomycin D and DTIC [dacarbazine] was administered to 20 evaluable patients with metastatic soft tissue sarcoma. Responses included 4 (20%) partial remissions and 5 (25%) patients with stable disease. There was a significant prolongation of survival for responding patients (median 42.5 + wk) compared to patients with progressive disease (median 17.5 wk). Principal toxicity was nausea and vomiting particularly with the actinomycin D/DTIC combination; 4 patients found this so intolerable they withdrew from study. These results are inferior to those reported for adriamycin alone and other combinations. Further evaluation of the concept of sequential non-cross-resistant combinations would only seem appropriate if newer more active agents are identified and each combination is administered for a set duration before crossing over to the alternative regimen.

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