Hereditary Haemolytic Anaemia due to an Abnormal Haemoglobin (Haemoglobin Kings County)

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Abstract
Two patients in an American Negro family with a hereditary non‐spherocytic haemolytic Heinz‐body anaemia, mesobilifuscinuria, and an abnormal haemoglobin have been studied. The absence of any abnormality in the red cell metabolism and the presence of a thermolabile fraction of the haemoglobin constituting 10 per cent of the patients’total haemoglobin make us believe that the cause of the haemolysis is the abnormal haemoglobin. Since this haemoglobin appears to differ from all the other abnormal haemoglobins described in patients having congenital non‐spherocytic haemolytic anaemia, a new name (haemoglobin Kings County) is proposed for it.