INHIBITION OF SODIUM-POTASSIUM-ACTIVATED ADENOSINE 5'-TRIPHOSPHATASE AND ION-TRANSPORT BY ADRIAMYCIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (1) , 257-261
Abstract
The antitumor antibiotic adriamycin is a potent inhibitor of the Na-K-activated ATPase of native [rabbit] heart microsomes. Adriamycin also inhibits K transport (although not Na transport) in slices of kidney cortex. The effects on both the ATPase and ion transport are markedly reduced by Ca2+, probably by chelation of this metal by adriamycin. These effects could provide a basis for explaining the adriamycin cardiotoxicity as digitalis-type toxicity.