BREAKDOWN PRODUCTS OF C3 AND FACTOR-B IN HEMOLYTIC-UREMIC SYNDROME

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 89  (4) , 845-850
Abstract
Serum concentrations of Clq [q fragment of the 1st complement component], C4, C3 and factor B but not properdin were significantly decreased in patients with HUS [hemolytic-uremic syndrome] compared to values in normal control subjects (P value < 0.01). Sera from 13 HUS patients obtained early after the onset of the disease showed breakdown products of Factor B (Ba, Bb) by immunoelectrophoresis; 12 of these sera showed C3 breakdown products (C3c, C3d). Sera from 7 patients studied 1 mo. to 3 yr later no longer demonstrated any breakdown products of Factor B or C3. The C system is probably activated in HUS. The concept that immunological mechanisms play a major role in this disease is supported by the occurrence of Ig[immunoglobulin]M, C3 and fibrin in glomeruli and renal vessels.

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