IV. Chemotherapy of Tumors in Rats with Piperazine-l,4-bis (N,N'-diethylenephosphondiamide).

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Abstract
Piperazine- 1, 4-bis (N,N[image]-diethylenephosphondiamide) (PDA) in doses up to 1 mg/kg /day for 4-6 weeks produced no significant toxic reaction in rats; at higher doses there was some leukopenia but it was not serious, even with doses of 3.0-4.5 mgAg/day given for 4-6 weeks. Flexner-Jobling carcinoma regressed completely in 30% of rats treated with .2 mg/kg/ day of PDA and in about 90% of those with 3.5 mgAg/day. There were no regressions among the controls 34 days after implantation. Growth of sarcoma Rl in Wistar rats was retarded about 50% by the product at 3 mgAg/day. Walker 256 carcinosarcoma was retarded in growth by doses of 1-3 mgAg/day and inhibited for about 2-3 weeks with a dose of 4.5 mgAg/day. After initial period of growth inhibition the Walker tumor became resistant to the drug and then grew rapidly in spite of continued therapy.

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